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FLAVINE-ADENINE-DINUCLEOTIDE, DISODIUM

Flavine adenine dinucleotide disodium salt

CAS: 84366-81-4

Molecular Formula: C27H34N9NaO15P2

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FLAVINE-ADENINE-DINUCLEOTIDE, DISODIUM - Names and Identifiers

Name Flavine adenine dinucleotide disodium salt
Synonyms FAD
FAD-N
FAD-NA2
FAD 2NA
FAD DISODIUM SALT
FLAVINE-ADENINE-DINUCLEOTIDE, DISODIUM
Flavin adenine dinucleotide disodium salt
Flavine adenine dinucleotide disodium salt
RIBOFLAVIN 5'-ADENOSINE DIPHOSPHATE DISODIUM SALT
Riboflavin 5'-(trihydrogen diphosphate), 5'.5'-ester with adenosine, disodium salt
disodium [(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxy-tetrahydrofuran-2-yl]methyl [[5-(7,8-dimethyl-2,4-dioxo-benzo[g]pteridin-10-yl)-2,3,4-trihydroxy-pentoxy]-oxido-phosphoryl] phosphate
disodium [(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxy-tetrahydrofuran-2-yl]methyl [[(2R,3S,4S)-5-(7,8-dimethyl-2,4-dioxo-benzo[g]pteridin-10-yl)-2,3,4-trihydroxy-pentoxy]-oxido-phosphoryl] phosphate
CAS 84366-81-4
EINECS 282-733-8
InChI InChI=1/C27H33N9O15P2.2Na/c1-10-3-12-13(4-11(10)2)35(24-18(32-12)25(42)34-27(43)33-24)5-14(37)19(39)15(38)6-48-52(44,45)51-53(46,47)49-7-16-20(40)21(41)26(50-16)36-9-31-17-22(28)29-8-30-23(17)36;;/h3-4,8-9,14-16,19-21,26,37-41H,5-7H2,1-2H3,(H,44,45)(H,46,47)(H2,28,29,30)(H,34,42,43);;/q;2*+1/p-2/t14?,15?,16-,19?,20-,21-,26-;;/m1../s1

FLAVINE-ADENINE-DINUCLEOTIDE, DISODIUM - Physico-chemical Properties

Molecular FormulaC27H34N9NaO15P2
Molar Mass809.55
Melting Point>203°C (dec.)
Specific Rotation(α)α20/D -30.0° to -25.0°, c = 1 in water
Water Solubility5 g/L
Solubility water: 50 mg/mL
Appearanceyellow to orange-brown(powder)
Coloryellow to orange-brown
Merck14,4091
BRN5326842
Storage Condition2-8°C
StabilityHygroscopic
SensitiveSensitive to light and easy to absorb moisture
MDLMFCD08277021
In vitro study Poly(Flavin adenine dinucleotide, FAD) characterized by an additional polymer-type redox reaction is a highly effective electrocatalyst for NADH oxidation: operating at the lowest potentials reported for NADH transducers (0.00 V, pH 7.4), poly(FAD) is characterized by the electrochemical rate constant of 1.8 ± 0.6×10 -3 cm/s, which is at the level of the NADH mass-transfer constant. Poly(FAD)-modified electrodes are characterized by the dramatically improved stability and, is the most advantageous NADH transducers for analytical chemistry.
In vivo study With Flavin adenine dinucleotide (2 mg/kg), the chlorpromazine (CPZ)-induced decrease in ventricular fibrillation threshold (VFT) is significantly cancelled. Flavin adenine dinucleotide cancels the effect of CPZ on canine heart mitochondria. After injection of Flavin adenine dinucleotide, the dogs show a transient hypotension within 10 min, then their blood pressures recover to the initial level. Flavin adenine dinucleotide also prevents mitochondrial dysfunction induced by chlorpromazine.

FLAVINE-ADENINE-DINUCLEOTIDE, DISODIUM - Risk and Safety

Safety DescriptionS24/25 - Avoid contact with skin and eyes.
S22 - Do not breathe dust.
WGK Germany3
RTECSAU7470000
FLUKA BRAND F CODES8-10-21
HS Code29339900

FLAVINE-ADENINE-DINUCLEOTIDE, DISODIUM - Reference

Reference
Show more
1. Nianyuan, Deng Yuanyuan, Wei Zhencheng, Zhang Yan, Tang Xiaojun, Li Ping, Zhou Pengfei, Liu Guang, Zhang famous. Expression and enzymatic characteristics of recombinant wheat resting thiol oxidase and its effect on bread quality [J]. Chinese Journal of bioengineering, 2021,37(02):593-603.
2. Zhao T, Li Y, Yuan S, et al. Structure-Based Design of Acetolactate synthesis From Bacillus licheniformed Improved Protein. Front Microbiol. 2020;11:582909. Published 2020 Oct 27. doi:10.3389/fmicb.2020.582909
3. [IF = 1.902] Yu Sun et al."Characterization of sleep-related neurochemicals at different developmental stages and insomnia models." Biomedical Chromatography. 2022 Feb 01

FLAVINE-ADENINE-DINUCLEOTIDE, DISODIUM - Nature

Open Data Verified Data

orange yellow powder, hygroscopic, soluble in water, insoluble in ethanol, yellow green fluorescent aqueous solution, alkali decomposition into riboflavin. This product is present in the body of the active type riboflavin, it is as a certain oxidoreductase auxiliary group, widely involved in various redox reactions in the body, in the biological oxidation system plays a role in the transfer of hydrogen. It is characterized by higher solubility and utilization ratio than riboflavin, and the dosage is only (100/10) ~ (/10) of ordinary riboflavin, which can be used for intramuscular and intravenous injection.

Last Update：2024-01-02 23:10:35

FLAVINE-ADENINE-DINUCLEOTIDE, DISODIUM - Introduction

Solubility in water: 5g/l
Last Update：2022-10-16 17:29:19

FLAVINE-ADENINE-DINUCLEOTIDE, DISODIUM - Use

Open Data Verified Data
  • it is suitable for skin and mucous membrane diseases, nervous tinnitus, cerebral arteriosclerosis, intractable Head Pain, cirrhosis, jaundice and other liver diseases, eye diseases and retinal diseases.
  • usage and dose of oral, each 5~15mg, 1~3 times a day. Subcutaneous, intramuscular injection, intravenous injection, each time 1~10 mg, 1~2 times a day. Ophthalmic use, several times a day.
Last Update：2022-01-01 11:13:05

FLAVINE-ADENINE-DINUCLEOTIDE, DISODIUM - Safety

Open Data Verified Data

temporary chest discomfort was noted after too fast intravenous injection.

Last Update：2022-01-01 11:13:05

FLAVINE-ADENINE-DINUCLEOTIDE, DISODIUM - Reference Information

, several important enzymatic reactions are involved in metabolic processes.
biological activity
purposes mainly used for styrene-butadiene rubber and other polymer emulsion catalyzed polymerization preparation of emulsifier
flavoprotins redox coenzyme
used as redox cofactor of flavoprotein (Electron carrier), these flavoprotein include succinate dehydrogenase (complex), α-ketoglutarate dehydrogenase, apoptosis-inducing factor 2(AIF-M2, amide), folate/FAD-dependent tRNA methyltransferase and N-hydroxylated flavoprotein monooxygenase. FAD is a component of the pyruvate dehydrogenase complex.
Last Update：2024-04-09 20:52:54
FLAVINE-ADENINE-DINUCLEOTIDE, DISODIUM
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Shanghai Yuanye Bio-Technology Co., Ltd.
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CAS: 84366-81-4
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CAS: 84366-81-4
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Shanghai Yuanye Bio-Technology Co., Ltd.
Multiple SpecificationsSpot supply
Product Name: Flavin adenine dinucleotide disodium salt hydrate Visit Supplier Webpage Request for quotation
CAS: 84366-81-4
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409 Click to send a QQ message
Wechat: 18301782025
Shenzhen Hygieia Biotechnology Co., Ltd
Product Name: Flavin adenine dinucleotide disodium salt Request for quotation
CAS: 84366-81-4
Tel: 0755-27208059
Email: alex@hygieia.com.cn
Mobile: 13342904611
QQ: 3445655213 Click to send a QQ messageSend QQ message
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FLAVINE-ADENINE-DINUCLEOTIDE, DISODIUM
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